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This medication works by narrowing blood vessels around the brain. Com. Imitrex Information. 8 stars, based on 71 comments. Imitrex, or Sumatriptan as it is also known, is a drug that is used to treat headaches by narrowing blood vessels around the brain. Important Safety Information & Side Effects: Imitrex should be taken exactly as prescribed by your doctor, but typically taken at the first sign of a migraine What Imitrex is and what it is used for. How To Use. Imitrex injections can be given by the user of the medicine or Read More. We recommend you learn more from the FDA at the BeSafeRX —Know Your Online Pharmacy page and first verify your pharmacy before making online health purchases. Where can I buy sumatriptan (generic Imitrex®)? Nov 07, 2019 · Imitrex will only treat a headache that has already begun. Until you know how Imitrex DF will affect you, do not drive, operate machinery, or attempt any actions that may be unsafe if you are not alert. 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